Hereditary Angioedema and Mental Health

Hereditary Angioedema (HAE) is a rare and potentially life-threatening genetic condition in which patients can develop HAE ‘attacks’ that include episodes of edema (swelling) in various regions of the body including the hands, feet, face and airway.  Swelling in the airway can lead to death by asphyxiation.

This chronic condition, especially in the recent past, was associated with a plethora of stressors – physically, financially, and emotionally.  One recent study found anxiety and depression to be high in HAE patients.

Recently, we talked to lead investigator of that study, Timothy Craig, DO, Allergy, Immunology, and Respiratory Medicine at Penn State Hershey Medical. In this interview, Dr Craig talks about the study and why many of those patients are anxious and depressed.

For more information about HAE, visit

Fouche AS, Saunders EF, Craig T. Depression and anxiety in patients with hereditary angioedema. Ann Allergy Asthma Immunol. 2014;112(4): 371-375.
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