Efficacy of Brentuximab Vedotin in Treating Cutaneous t-cell Lymphoma

Ashish Gautma, PhD, MBA

Cutaneous T-cell lymphoma is a rare form of lymphoma that has a poor prognosis when advanced.

Ashish Gautma, PhD, MBA of Takeda Oncology talks about the lasted results from the ALCANZA study that was presented at the 58th Annual ASH Meeting & Exposition.

ALCANZA enrolled 128 previously treated patients with CD-30–expressing cutaneous T-cell lymphoma. They were randomized to receive brentuximab vedotin (1.8 mg/kg intravenously) once every 3 weeks or physician’s choice [oral methotrexate (5–50 mg once weekly) or oral bexarotene (300 mg/m2 once daily for up to 16 weeks).

At 17.5 months of follow-up, the overall response was significantly higher for brentuximab vedotin than for physician’s choice of therapy: 56% vs 13%, respectively (P < .0001). Median progression-free survival was also significantly higher in the brentuximab-treated group: 16.7 months vs 3.5 months (P < .0001).


Kim YH, Whittaker S, Horwitz SM, et al. Brentuximab Vedotin Demonstrates Significantly Superior Clinical Outcomes in Patients with CD30-Expressing Cutaneous T Cell Lymphoma Versus Physician's Choice (Methotrexate or Bexarotene): The Phase 3 Alcanza Study. Presented at 58th Annual ASH Meeting & Exposition; San Diego, CA; 
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