Pompe disease is a rare lysosomal disease that may present in childhood (early-onset) or in adulthood (late-onset). In both cases, the disease is due to a deficiency in the enzyme alpha-glucosidase (GAA). Symptoms vary greatly in this population but can be severe and ultimately deadly in the early-onset type. Patients with laste-onset Pompe disease will often grow up being able to walk but begin to lose muscle stength as they age. Many of these patients will require technology to help them be ambulatory.