Castleman or Castleman's disease is not a cancer but is a lymphoproliferative disorder involving an overgrowth (proliferation) of lymphatic cells. Castleman's disease affects the lymph nodes and may require treatment with surgery, chemotherapy and/or radiation therapy. Castleman's disease is also referred to as giant lymph node hyperplasia, or angiofollicular lymph node hyperplasia.
In this exclusive interview with Rare Disease Report, Dr Nikhil Munshi of the Dana-Farber Cancer Institute talks about methods used to diagnose these patients. To differentiate Castleman's disease from lymphoma or other lymphatic disorders, a lymph node biopsy is necessary and a pathologist familiar with Castleman's disease may be needed to confirm the diagnosis.